Tag: brain

A Meta View on the Skin: What are the components of skin communication?

Focus on intra- and extracellular vesicles, and different skin cells

By Anaïs BONNEFOY

In the previous articles, we reviewed the interconnections of the skin. We began by exploring its interface with the external environment, then examined its links with the human body, and finally discovered communication within the cells themselves. Connections between the skin and its external environment, as well as with other components of the human body such as the brain and the skin microbiota, are made possible thanks to coordinated communication between skin cells. This final part of the “Meta View on the Skin” series examines the mechanisms of intercellular communication within the skin.

A Meta View on the Skin: Interactions between skin and human body ecosystems

Skin–brain axis, skin–microbiome interconnections

Par Anaïs BONNEFOY

In recent years, two highly dynamic research fields have emerged, highlighting the essential role of the skin within a complex network of interactions with other physiological systems. On the one hand, work on the skin–brain axis has improved understanding of the skin’s neural mechanisms and how they can be modulated. On the other hand, research on the skin microbiome has deepened knowledge of the microbial ecosystem living on the skin surface and its role in maintaining cutaneous homeostasis.

The first part of this article describes the mechanisms linking the skin and the brain. The second part focuses on interactions between the skin and the microbiome.