A Meta View on the Skin: A dynamic interface connected with its environment

Review of the main external factors influencing immune processes and cutaneous homeostasis

By Anaïs BONNEFOY

Skin condition is often perceived as a tangible testimony of the passage of time, but it also reflects the environments in which an individual has evolved. It is therefore not uncommon, especially among informed observers, to rely on imagination to sketch stereotypical assumptions about a person’s past experiences. For instance, the presence of numerous age-related pigmentation spots, known as lentigines, may suggest prolonged sun exposure over many summers (and without adequate protection…). Conversely, a “baby-like” skin appearance at an advanced age may imply a healthy lifestyle (and possibly a favourable genetic background…).